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Intervax Ltd bcg vaccine strain bulgaria
Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of <t>the</t> <t>300BCG</t> cohort. (B) Heatmap of SNPs that show a significant association with the capacity of <t>β-glucan/BCG-induced</t> trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.
Bcg Vaccine Strain Bulgaria, supplied by Intervax Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bcg+vaccine+strain+bulgaria/bcg+vaccine+strain+bulgaria/pmc12141851-107-11-16
Average 90 stars, based on 1 article reviews
bcg vaccine strain bulgaria - by Bioz Stars, 2026-10
90/100 stars

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Article Title: C1q reprograms innate immune memory

Journal: Frontiers in Immunology

doi: 10.3389/fimmu.2025.1515127

Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of β-glucan/BCG-induced trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.
Figure Legend Snippet: Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of β-glucan/BCG-induced trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.

Techniques Used: In Vitro, In Vivo

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In Vitro:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

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In Vivo:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Control:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
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Article Title: C1q reprograms innate immune memory
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Lysis:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
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Article Title: The role of sirtuin 1 on the induction of trained immunity.
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Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
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Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Incubation:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Negative Control:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Isolation:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

RNA Sequencing:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Gene Expression:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Software:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Ex Vivo:

Article Title: RORα negatively regulates BCG-induced trained immunity.
Article Snippet: After receiving the written informed consent, the blood was drawn and the individuals were vaccinated with a standard dose of 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada) intradermally in the left upper arm.

Article Title: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated in the morning with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax).

Article Title: The role of sirtuin 1 on the induction of trained immunity.
Article Snippet: Furthermore, individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; InterVax, Canada), and PBMCs were isolated, and stimulated ex vivo with 5 × 106 CFU/mL heat-killed S. aureus before vaccination, and 2 weeks and 3 months after vaccination.

Article Title: Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes
Article Snippet: EXPERIMENTAL MODEL AND SUBJECT DETAILS Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: C1q reprograms innate immune memory
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Article Title: An integrative genomics approach identifies KDM4 as a modulator of trained immunity.
Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 mL of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).



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Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of <t>the</t> <t>300BCG</t> cohort. (B) Heatmap of SNPs that show a significant association with the capacity of <t>β-glucan/BCG-induced</t> trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.
Bcg Vaccine Strain Bulgaria, supplied by Intervax Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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90/100 stars
  Buy from Supplier

90
Intervax Ltd bacillus calmette–guérin vaccine bcg strain bulgaria
Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of <t>β-glucan/BCG-induced</t> trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the <t>BCG</t> <t>vaccine-induced</t> trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.
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Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of <t>β-glucan/BCG-induced</t> trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the <t>BCG</t> <t>vaccine-induced</t> trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.
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90
Intervax Ltd bcg vaccine bulgaria strain
Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of <t>β-glucan/BCG-induced</t> trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the <t>BCG</t> <t>vaccine-induced</t> trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.
Bcg Vaccine Bulgaria Strain, supplied by Intervax Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bcg+vaccine+strain+bulgaria/bcg+vaccine+strain+bulgaria/pm36681271-209-12-17
Average 90 stars, based on 1 article reviews
bcg vaccine bulgaria strain - by Bioz Stars, 2026-10
90/100 stars
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90
Intervax Ltd bcg (bcg vaccine strain bulgaria)
Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of <t>β-glucan/BCG-induced</t> trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the <t>BCG</t> <t>vaccine-induced</t> trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.
Bcg (Bcg Vaccine Strain Bulgaria), supplied by Intervax Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bcg+vaccine+strain+bulgaria/bcg+vaccine+strain+bulgaria/pmc08970681-279-14-19
Average 90 stars, based on 1 article reviews
bcg (bcg vaccine strain bulgaria) - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

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Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of β-glucan/BCG-induced trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.

Journal: Frontiers in Immunology

Article Title: C1q reprograms innate immune memory

doi: 10.3389/fimmu.2025.1515127

Figure Lengend Snippet: Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of β-glucan/BCG-induced trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.

Article Snippet: Individuals from the 300BCG cohort were vaccinated with 0.1 ml of BCG (BCG vaccine strain Bulgaria; Intervax, Canada).

Techniques: In Vitro, In Vivo

Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of β-glucan/BCG-induced trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.

Journal: Frontiers in Immunology

Article Title: C1q reprograms innate immune memory

doi: 10.3389/fimmu.2025.1515127

Figure Lengend Snippet: Single nucleotide polymorphisms in the proximity of genes encoding C1q components associate with innate immune memory responses. (A) Schematic representation of the in-vitro training experiments followed by QTL analysis using single nucleotide polymorphism (SNP) genotypes of volunteers of the 300BCG cohort. (B) Heatmap of SNPs that show a significant association with the capacity of β-glucan/BCG-induced trained immunity ( n = 267 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, and negative = SNP decreases the fold change of cytokine production). (C) Associations of SNPs rs294179, rs1561624 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after β-glucan training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs294179 and rs1561624. (D) Associations of SNPs rs666656, and rs913243 near C1q with the cytokine responses after 24h restimulation with LPS (10 ng/ml), 5 days after BCG training ( n = 267 donors). Boxplots show the genotype stratified fold changes in IL-6 and TNF responses for SNPs rs666656 and rs913243. (E) Schematic representation of the in-vivo training experiments followed by QTL analysis using SNP genotypes of volunteers of the 300BCG cohort. (F) Heatmap of SNPs that show a significant association with the capacity of the BCG vaccine-induced trained immunity ( n = 278 donors). Beta shows the direction of the effect (positive = SNP increases the fold change of cytokine production upon training, negative = SNP decreases the fold change of cytokine production) (G) Associations of SNPs rs10917276 and rs79073090 near C1q with the cytokine responses after vaccination with Bacillus Calmette–Guérin (BCG) vaccine ( n = 278 donors). Boxplots show the genotype stratified fold changes in IL-1β and TNF responses for SNPs rs10917276 and rs79073090, respectively.

Article Snippet: After washing, PBMCs were incubated with culture medium only as a negative control, heat-killed Candida albicans (HKCA), 10 5 cells/ml (InvivoGen, Toulouse, France), Bacillus Calmette–Guérin (BCG) vaccine (5 μg/ml, BCG strain Bulgaria, Intervax) that acted as a positive control, or a complement factor for 24h at 37°C.

Techniques: In Vitro, In Vivo